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蛋白質(zhì)藥物具有潛在的免疫原性，可能誘導(dǎo)人體產(chǎn)生抗藥物抗體（Anti-Drug Antibodies，ADAs）。ADAs可能降低藥物療效，或者引起過敏反應(yīng)，甚至威脅生命。

監(jiān)測蛋白質(zhì)藥物的潛在免疫反應(yīng)（Immune response，IR）已成為藥物開發(fā)和上市后的監(jiān)管要求。常用檢測包括：對結(jié)合藥物抗體的檢測、抗藥物中和抗體檢測等。制備抗體用于臨床樣品中ADAs檢測成為必要，同時該抗體也可用于蛋白藥物的PK/PD研究中。

抗體藥物已成為生物制藥領(lǐng)域研究熱點(diǎn)?？躬?dú)特型（Anti-idiotype）抗體主要用于檢測血液中特異性抗體藥物的含量，包括游離型、結(jié)合型和總量，在抗體藥物研發(fā)領(lǐng)域起著舉足輕重的作用。

An anti-idiotype antibody (anti-ID Ab) is able to recognize and bind to the idiotype of another antibody. Youkebio has various solutions to problems that you may encounter during the development of anti-idiotype antibodies. We can offer a full range of services - from antigen preparation, anti-idiotypic antibody development to detection method establishment and kit development.
Anti-idiotype antibodies are widely used in therapeutic drugs studies:
? Antibody drug immunogenicity studies
? Vaccine development
? Anti-drug antibodies (ADA) for clinical development
? Antibody drug pharmacokinetic/pharmacodynamics (PK/PD) studies: detecting free, total or bound drug in blood