Anti-DXD antibody,mAb - Biotin標記
抗Dxd鼠單克隆抗體-生物素標記
編號：YKMP18020B
貨期：現貨
規(guī)格：25ul/100ul/1ml
Background
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43 nM-4.07 nM, but the control IgG-ADC (Dxd is the payload) shows no inhibition on the four cell lines (with HER2 expression). DS-8201a (Dxd is the payload) displays significant suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines, with IC50 values of 26.8, 25.4, and 6.7 ng/mL, respectively, but with no such inhibition on MDA-MB-468 (IC50, >10,000 ng/mL).
相關產品：
Anti- Dxd (Exatecan derivative for ADC) antibody, mAb
抗Dxd鼠單克隆抗體
編號：YKMP18020
規(guī)格：25ug/100ug/1mg （可詢價）
Anti- Dxd antibody, mAb, mAb-HRP標記
抗Dxd鼠單克隆抗體-HRP標記
編號：YKMP18020H
貨期：現貨
規(guī)格：25ul/100ul/1ml
